BIOMEDE 5470
Transcript Abbreviation:
Cell Mechanics
Course Description:
This course will focus on the application of mechanics to biological cells and tissues. We will explore experimental methods used to measure mechanical properties of cells and tissues and mathematical models used to interpret experimental observations of cell and tissue mechanics. Computational mechanics and FE models will be used to investigate cell and tissue mechanics.
Course Levels:
Undergraduate (1000-5000 level)
Graduate (5000-8000 level)
Designation:
Elective
General Education Course:
(N/A)
Cross-Listings:
(N/A)
Credit Hours (Minimum if “Range”selected):
3.00
Max Credit Hours:
3.00
Select if Repeatable:
Off
Maximum Repeatable Credits:
(N/A)
Total Completions Allowed:
(N/A)
Allow Multiple Enrollments in Term:
No
Course Length:
14 weeks (autumn or spring)
12 weeks (summer only)
Off Campus:
Never
Campus Location:
Columbus
Instruction Modes:
In Person (75-100% campus; 0-24% online)
Prerequisites and Co-requisites:
Prereq: 4410, and MechEng 2040, and Sr standing; or Grad standing; or permission of instructor.
Electronically Enforced:
No
Exclusions:
Not open to students with credit for 740.
Course Goals / Objectives:
Describe basic guidelines for modeling the biomechanical properties of cells and tissues and the common types of models used in biomechanics
Analyze lumped-parameter models of tissue viscoelasticity
Use composite theory to calculate the effective elastic modulus of the heterogeneous tissues and extracellular matrix
Describe the linear and non-linear mechanical properties of the cytoskeleton
Describe the experimental techniques used to characterize cell and tissue mechanics
Analyze experimental data obtained from AFM based measurements of cell mechanics
Use complex numbers to derive the frequency dependence of the cell?s storage and loss moduli
Read and understand current literature in the field of cell and tissue mechanics
Use computational modeling to investigate hypothesis generated from the current literature
Check if concurrence sought:
No
Contact Hours:
| Topic | LEC | REC out-of-class | REC in-class | Weekly LAB out-of-class | Weekly LAB in-class |
|---|---|---|---|---|---|
| Introduction to Cell mechanics | 2.0 | 0.0 | 0 | 0.0 | 0 |
| Application of mechanics to cell biology | 2.0 | 0.0 | 0 | 0.0 | 0 |
| Statistical mechanics | 2.0 | 0.0 | 0 | 0.0 | 0 |
| Biofilaments (Ropes and Rods) | 4.0 | 0.0 | 0 | 0.0 | 0 |
| 2D networkds and entropic elasticity | 4.0 | 0.0 | 0 | 0.0 | 0 |
| Tensegrity models and 3D netowrks | 4.0 | 0.0 | 0 | 0.0 | 0 |
| Viscoelastic models | 2.0 | 0.0 | 0 | 0.0 | 0 |
| Mechanics of Biomembranes | 4.0 | 0.0 | 0 | 0.0 | 0 |
| Measurements of cell mechanics | 6.0 | 0.0 | 0 | 0.0 | 0 |
| Membrane Energetics and simple cell shapes | 4.0 | 0.0 | 0 | 0.0 | 0 |
| Cell Motility and Filament Dyanmics | 2.0 | 0.0 | 0 | 0.0 | 0 |
| Mechanotransduction | 2.0 | 0.0 | 0 | 0.0 | 0 |
| Student Presentations | 4.0 | 0.0 | 0 | 0.0 | 0 |
| Total | 42 | 0 | 0 | 0 | 0 |
Grading Plan:
Letter Grade
Course Components:
Lecture
Grade Roster Component:
Lecture
Credit by Exam (EM):
No
Grades Breakdown:
| Aspect | Percent |
|---|---|
| Homework | 25% |
| Mid-term | 20% |
| Final | 35% |
| Term project - paper and presentation | 20% |
Representative Textbooks and Other Course Materials:
| Title | Author | Year |
|---|---|---|
| Mechanics of the Cell, Cambridge Univ. Press, 2002 | D. Boal |
ABET-CAC Criterion 3 Outcomes:
(N/A)
ABET-ETAC Criterion 3 Outcomes:
(N/A)
ABET-EAC Criterion 3 Outcomes:
(N/A)
Embedded Literacies Info: