BIOMEDE 5210
Transcript Abbreviation:
Adv Biotransport
Course Description:
Theoretical and phenomenological derivation and applications of transport (momentum, mass and energy) concepts important for biological systems and motivated by biomedical problems.
Course Levels:
Undergraduate (1000-5000 level)
Graduate (5000-8000 level)
Designation:
Elective
General Education Course:
(N/A)
Cross-Listings:
(N/A)
Credit Hours (Minimum if “Range”selected):
3.00
Max Credit Hours:
3.00
Select if Repeatable:
Off
Maximum Repeatable Credits:
3.00
Total Completions Allowed:
(N/A)
Allow Multiple Enrollments in Term:
No
Course Length:
14 weeks (autumn or spring)
12 weeks (summer only)
Off Campus:
Never
Campus Location:
Columbus
Instruction Modes:
In Person (75-100% campus; 0-24% online)
Prerequisites and Co-requisites:
Prereq: 4210 or equiv, and Sr standing; or Grad standing; or permission of instructor.
Electronically Enforced:
No
Exclusions:
Not open to students with credit for 621 or 721.
Course Goals / Objectives:
Define each term in the overall equation of continuity, the equation of continuity for a species, the laws of diffusion, and the Navier-Stokes equation of motion
Apply momentum and mass balances to describe standard transport problems, and when possible, solve them analytically
Utilize (and, in certain cases, solve analytically) the same conservation equations to describe biotransport problems
Check if concurrence sought:
No
Contact Hours:
| Topic | LEC | REC out-of-class | REC in-class | Weekly LAB out-of-class | Weekly LAB in-class |
|---|---|---|---|---|---|
| Definition of transport processes. Derivation of species mass balance equation and equation of continuity. Fick’s laws of diffusion. Review conservation equations: continuity, momentum, energy, species mass balances. Important dimensionless groups. | 9.0 | 0.0 | 0 | 0.0 | 0 |
| Applications of mass balances: Unsteady diffusion with a heterogeneous reaction (reaction on a surface). Importance of boundary conditions. Multicomponent diffusion: Stefan-Maxwell equations. | 9.0 | 0.0 | 0 | 0.0 | 0 |
| Constitutive relations (Newton’s law of viscosity, non-Newtonian rheology). Applications of momentum balances (Pressure-driven flow; Flow through cylindrical tube; Pulsatile flow through cylindrical tube with rigid walls). | 6.0 | 0.0 | 0 | 0.0 | 0 |
| Modeling the blood oxygenator (Unsteady 1-D diffusion of oxygen in a semi-infinite medium). Modeling the dialysis machine (Artificial kidney; Convective mass transfer with reaction at the boundary). | 3.0 | 0.0 | 0 | 0.0 | 0 |
| Example of convective mass transport. Boundary layer theory. | 3.0 | 0.0 | 0 | 0.0 | 0 |
| Diffusion- vs. reaction-limited mass transfer (Blood platelet transfer to the vessel wall). Unsteady mass transfer with diffusion and reaction (A mutagen bioassay). | 3.0 | 0.0 | 0 | 0.0 | 0 |
| Whole-cell kinetic models (Ligand-receptor kinetics on the cell surface and molecular transport within cells). Mass transport in tissues and organs (Pharmacokinetic models). Biochemical reaction kinetics. Mass transfer through a porous media. | 6.0 | 0.0 | 0 | 0.0 | 0 |
| Presentation of paper projects by student teams. | 3.0 | 0.0 | 0 | 0.0 | 0 |
| Total | 42 | 0 | 0 | 0 | 0 |
Grading Plan:
Letter Grade
Course Components:
Lecture
Grade Roster Component:
Lecture
Credit by Exam (EM):
No
Grades Breakdown:
| Aspect | Percent |
|---|---|
| Homework | 20% |
| Midterm exam | 25% |
| Final exam | 30% |
| Student project (based on research papers) | 20% |
| Class attendance | 5% |
Representative Textbooks and Other Course Materials:
| Title | Author | Year |
|---|---|---|
| "Transport Phenomena in Biological Systems", 2nd edition | GA Truskey, F Yuan, DF Katz. Publisher: Pearson Prentice Hall. Year: 2009 |
ABET-CAC Criterion 3 Outcomes:
(N/A)
ABET-ETAC Criterion 3 Outcomes:
(N/A)
ABET-EAC Criterion 3 Outcomes:
(N/A)
Embedded Literacies Info: